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INTRODUCTION Glutathione (GSH), the major intracellular thiol compound, is a ubiquitous tripeptide produced by most mammalian cells and it is the main mechanism of antioxidant defense against reactive oxygen species (ROS) and electrophiles

Pharmacological action comparison between cornu antelopis and cornu caprae hircus

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Washing Once the GST-tagged protein is bound to the glutathione resin, the column is washed to remove non-specifically bound proteins and other contaminants

Hence, combining inhibitors of BRAF and glutamine metabolism has a more prominent therapeutic effect

We found that, while BSO-induced GSH depletion had no influence on basal levels of neuronal apoptosis or Puma expression, it strongly enhanced H 2 O 2 -induced Puma induction and apoptosis (Fig