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Granulomatous infectious diseases associated with tumor necrosis factor antagonists

Most cases are asymptomatic, but they can cause loss of vision in up to 12% of patients37 or provoke early onset of puberty.35 In view of the high incidence of ONGs, close ophthalmological follow-up is advisable in children with NF1, whether this is clinical or radiological, as clinical detection by physical examination can be difficult and some neuropediatricians prefer conducting complementary tests (Fig