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Nat Commun 16 , 3748 (2025)

Figure 1 2 Cirrhosis-related malaise, fatigue, or lethargy 2.1 Definitions and prevalence Malaise embodies a pervasive sense of discomfort, weakness, or unease, the precise origin of which proves elusive and closely intertwines with mental well-being ( 2.2 Mechanism and causes Muscle functionality and contractility can suffer impairment either at or beyond the neuromuscular junction, termed peripheral fatigue, or proximal to it, referred to as central fatigue