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To discriminate the effectiveness of drug candidates, for both the glutathione and senescence assays, we defined a signal range bounded by the values of the assay result for 0 Gy unirradiated and 15 Gy irradiated controls

Brewer, Jack D

150 NewcombW

The mechanistic hypothesis is elegant: BPC-157 initiates the early phase: local vasodilation, angiogenesis, growth factor expression, terrain preparation TB-500 takes over: mobilizes stem and progenitor cells, directs migration via G-actin, sculpts matrix remodeling Both peptides operate on complementary temporal scales (BPC early, TB later) and on distinct cellular targets (endothelium and growth factors for one, migratory cells for the other)

doi:10.1007/s00394-021-02654-5

Study 2 (NCT 00435136) This study randomized 404 HIV-infected patients with lipodystrophy and excess abdominal fat to receive either a 2 mg dose of EGRIFTA (1 mg/vial formulation) (N=270) or placebo (N=126)