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Despite the potential effects of reduced ATP concentration in neurons of transgenic mice [306], HDM was able to suppress the formation of oligomeric A40/A42 and markedly increase the glymphatic clearance of soluble A40 and A42 compared to untreated mice at the same age [242]

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Current proposed treatments were classified into two categories: (i) one-size-fits-all strategies, which can potentially be used to treat various MDs regardless of the underlying genetic mutation, and (ii) precision medicine approaches, aimed at treating a specific MDs with a particular mutation or distinct metabolic characteristic

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