8 GIPR deficiency in mice leads to impaired glucose tolerance with reduced cell function, 9 while GIP overexpression results in improved glucose tolerance, enhanced cell function, and resistance to highfat dietinduced obesity
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This understanding has guided the development of amylin analogues like cagrilintide that retain therapeutic benefits while eliminating aggregation risks
Discovery of a potent and long-acting Xenopus GLP-1-based GLP-1/glucagon/Y2 receptor triple agonist
1: Sikiric P, Barisic I, Udovicic M, Lovric Bencic M, Balenovic D, Strinic D, Posilovic GZ, Uzun S, Vranes H, Krezic I, Lozic M, Stambolija V, Premuzic Mestrovic I, Oreskovic LB, Kalogjera L, Strbe S, Sikiric S, Tomic L, Stupnisek M, Kordic M, Tvrdeic A, Seiwerth S, Boban Blagaic A, Skrtic A
Framing the diet discussion: moving past tribalism to practical frameworks for evaluating various dietary strategies [A: 5:00, V: 3:45]