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Metabolic Function and Transport of Cobalamin in Human Cell Cobalamin Chemical Forms and Activation of Cbl-Dependent Enzymes The upper ligand of Cbl has a major role in activation of the Cbl-dependent enzymes

Annual monitoring should include checking serum B12 levels and, if needed, MMA and homocysteine levels

Alkylating Agents: These drugs damage DNA

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Table S6: Topics on vitamin B12 deficiency with consistent results across studies in the literature

Clinical onset and course, response to treatment and outcome in 24 patients with the cblE or cblG remethylation defect complemented by genetic and in vitro enzyme study data