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Description

Excess folate intake has been linked to risk of nerve damage in older adults with B12 deficiency (7), and unmetabolized folic acid in plasma was associated with reduced natural killer cell cytotoxicity in postmenopausal women (8)

Ablation of de novo DNA methyltransferase Dnmt3a in the nervous system leads to neuromuscular defects and shortened lifespan

Therefore, targeting Flk1 signaling in the RPE may prevent the development of neovascular AMDlike pathologies, thereby providing a novel therapeutic rationale for the prevention of neovascular AMD