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Shoudai, K., Peters, J

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doi: 10.3389/fimmu.2020.572865 88 WynnTA

Such a non-protein cofactor is known as a "prosthetic group." R -lipoic acid functions as a prosthetic group for the biological activity of the following multienzyme complexes: The glycine cleavage system that catalyzes the decarboxylation of glycine coupled with the addition of a methylene group (-CH 2 ) to tetrahydrofolate to form 5,10-methylene tetrahydrofolate, an important cofactor in the synthesis of nucleic acids ( Figure 3 )

Genetic, epidemiological, and clinical research has indicated that lipid abnormalities, such as in low-density lipoprotein cholesterol (LDL-C), are critical factors in the occurrence and progression of CVDs