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Thus, this model was carried forward to evaluate the covariate effect using a stepwise covariate approach

Low aqueous solubility, extensive first-pass metabolism, and active efflux sharply curtail systemic exposure to many phytochemicals, inflating required doses and manufacturing costs

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TABLE 4 Application of plant-extract-derived nano-formulated pesticides and their efficacy in enhancing crop protection through disease suppression in fruits and vegetables

Pharmacological applications Many drugs used in routine clinical practice interfere with bilirubin metabolism by induction of HMOX1 that induces bilirubin production [120] or decreasing bilirubin clearance by inhibiting its uptake or biotransformation [110]

Unlike discovery-based approaches, MRM/SRM selectively monitors specific precursor ion-to-fragment ion transitions unique to target peptides (McShane et al., 2014)