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This process regulates intestinal calcium and phosphorus absorption, promotes bone mineralization, maintains calcium and phosphorus homeostasis, and participates in physiological processes such as immune regulation, cell proliferation, and differentiation, thereby safeguarding human health ( 2 D 3 inhibits the activity of CYP2R1 in the liver and 1-hydroxylase in the kidney via a negative feedback mechanism, thus preventing excessive vitamin D synthesis and activation, and maintaining vitamin D metabolic homeostasis ( Figure 2 )

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These findings support the notion of iron accumulation after TBI (Zhang et al., 2019)

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To view a copy of this licence, visit About this article Cite this article Yilmaz, Y., Aydemir, E

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