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In keeping with the reduced capacity of homocysteine-exposed endothelial cells to inhibit platelet aggregation, Lentz and collaborators demonstrated, using experimental hyperhomocysteinemia (induced by a diet depleted of folate, high in methionine, and choline-free) that the endothelial-dependent vasodilation is impaired in hyperhomocysteinemic primates

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It is now considered well-known that orally administered B12 supplements are as effective in overcoming deficiency states as intramuscular injections when you get up to taking 1,000 micrograms a day

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Insomnia: Sleep disturbances, including difficulty falling or staying asleep, may persist for some patients even with consistent use