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Inhibition of non-c-Met targets may enhance the antitumor activity of non-selective c-Met inhibitors, but is also correlated with increased toxicity and limits the dose so that inhibitors cannot effectively suppress c-Met (Bouattour et al., 2018)

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Currently, FINs have only demonstrated efficacy in a specific subset of patients with ovarian cancer (Wang et al., 2020)

Interestingly, in young APP/PS1 search strategy alterations could only been detected in male mice, while female APP/PS1 demonstrated the same search pattern as WT animals 27