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The percentage of hemolysis was calculated using the following formula: Biocompatibility assay The major organs, including the heart, liver, spleen, lungs, and kidneys of the previous CIA mouse models, were harvested from the euthanized mice for further H&E staining and histology assay to evaluate the toxicity of MCMs, SP, and SP@M

In addition, HSV-1 has been reported to induce apoptosis in brainstems of mice infected with this virus, in which significant TUNEL-staining was observed at day 6 post-infection, although with low levels of detectable infectious virus, suggesting death of cells that were bystander to those infected with HSV-1 (Shaw et al., 2002)

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Due to the strength of these doses, they require close monitoring to avoid saturation or unwanted detox responses

In animal models, faster regeneration of muscle fibers, tendons, and connective tissues has been observed

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