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4.4 Oxidative stress and mitochondrial function Oxidative stress (OS) denotes the potential harm to a cell's architecture and functionality caused by the generation and build-up of oxidizing agents, such as ROS, within and outside the cell

Neurotoxicology 37:163172

GSSG: no longer provides antioxidant protection must be recycled back into GSH to be useful again reflects how much oxidative stress the body is under High levels of oxidized glutathione signal high internal stress , not high glow

10.1242/DMM.048355 52 KatsarouA.MoustakasI

[79] A phase I trial of intravenous vitamin E in treatment refractory neuroblastoma found mild toxicity (tendency toward increased bleeding time was noted) at doses below 2,300 mg/m2