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Thus, the absence of arthritis had a 95% negative predictive value for advanced liver fibrosis, making it a simple clinical tool for ascertaining the risk of significant liver disease

This observation is reminiscent of our previous observations of the robustness of cytosolic glutathione redox homeostasis, which largely relies on robust NADPH supply, indicating that the robustness in NADP redox state also serves the stability of downstream redox pools [21]

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GGT transfers the -glutamyl residue of glutathione to amino acid acceptors (the best acceptor being cystine), releasing -glutamyl peptides and cysteinyl glycine

End stage cirrhosis Iron overload may be seen in cirrhosis