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In addition, the nongenetic surface modification of MSCs with sialyl Lewis X carbohydrate using a polyacrylamide linker and biotin/streptavidin interaction showed robust rolling on the endothelium and homed inflamed tissues in vivo more efficiently than unlabeled MSCs 46

Due to the compact nature of BBB, paracellular transportation of molecules is significantly restricted

GHK-Cu is a copper peptide commonly used in cosmetic formulas to support skin and scalp appearance

Targeted nanoparticles for drug delivery through the bloodbrain barrier for Alzheimer's disease

Wnt signaling blockage inhibits cell proliferation and migration, and induces apoptosis in triple-negative breast cancer cells

This Wnt-axis activity helps explain several otherwise disconnected observations why GHK-Cu promotes hair regrowth, why it extends fibroblast proliferative lifespan, and why it appears to reset certain senescence markers in aged skin cells