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Each of these degradation pathways accelerates at higher temperatures, and each one reduces how effectively tirzepatide activates the dual GIP/GLP-1 receptor system that drives its therapeutic effects

Several limitations and challenges must be addressed for the clinical translation of UA as follows

doi: 10.1093/pm/pny214 [DOI] [PubMed] [Google Scholar] 6

We did not observe any robust differences in the efficiency with which ER client proteins were secreted in hepatocytes treated with etomoxir compared to those that were not treated (data not shown)