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Chronic hyperglycemia induces excessive accumulation of advanced glycation end products (AGEs), enhanced oxidative stress, activation of inflammatory responses, and aberrant activation of the renin-angiotensin system (RAS)

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Biotechnology Journal 18: 2200398 (2023) Karunarathna I, Bandara S, Jayawardana A, de Alvis K, Gunasena P, Hapuarachchi T, Ekanayake U, Rajapaksha S, Gunawardana K, Aluthge P, Gunathilake S

Future strategies should aim at restoring balanced substrate utilization and protecting mitochondrial structure, rather than pursuing uniform suppression of FAO

This creates a positive feed-back loop and amplifies the RAGE ligand-mediated signal transduction

Commonly used oral agents include methotrexate, cyclosporine, acitretin, and apremilast, each with distinct mechanisms of action and efficacy profiles (Menter et al