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Material and methods Construction of plasmids expressing TAT-CcSOD1 fusion protein The TAT-CcSOD1 expression vectors were constructed by incorporating the coding sequences of HIV-1 TAT and CcSOD1 into the pET-24a vector

The GAA expansion mutation leads to reduction of the transcription of frataxin, a highly conserved nuclear-encoded mitochondrial protein involved in the biosynthesis of iron sulfur cluster (Fe-S) [2]

Enhanced responses of Th17 cells (IL-17, IL-23) and decreased responses of Treg cells (TGF-, IL-10) and high ratios of Th17/Treg cells in SARS-CoV-2-infected patients has a strong relationship with hyperinflammation, eosinophilic responses, allergic disorders, lung damage, and COVID-19 disease pathogenesis (293)

Independently tested for endotixins,sterility and benzyl alcohol level

April 29, 2026 Not for human consumption

SCFAs contribute to intestinal barrier integrity, modulating immune responses, and suppressing NF-B activity [47] (Fig