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In high-glucose conditions, increased GCN5L levels promote acetylation of fusion proteins MFN2 and OPA1, strengthening their membrane anchoring and facilitating mitochondrial network formation

245,312 Meanwhile, TAMs with high MAT2A expression also showed strong Met metabolic activity, increased histone H3K4 methylation level and receptor-interacting serine/threonine protein kinase 1 (RIPK1) gene expression

However: The research is not yet robust for large effect sizes, so expectations should be set accordingly

American Journal of Pharmacogenomics

10.3390/nu15214491 Nutrients 67 Martn GimnezV.de Las HerasN.LaheraV.TresguerresJ.ReiterR.ManuchaW