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Transgenic murine models for cognition Beyond chemical lesion models (scopolamine, 192-IgG-saporin), cognitive research has an arsenal of genetically modified strains that reproduce specific cognitive phenotypes: Alzheimer models 3xTg-AD (LaFerla): triple transgenic APP Swedish, PS1 M146V, tau P301L

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485 Due to the diversity and highly dynamic nature of SASP factors, different SASP factors may have opposite functions on each other, or some SASP factors may have contradictory multiple functions on themselves, which results in SASP factors having both tumor-suppressive and tumor-promoting effects

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The GABA(B) receptor-structure, ligand binding and drug development