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Upon activation, calcineurin dephosphorylates and stimulates TFEB, which in turn translocates into the nucleus where it binds to the coordinated lysosomal expression and regulation (CLEAR) sequence to upregulate expression of several genes involved in the autophagic pathway (Tong and Song, 2015

In principle, after hydrolysis of 13 C-labeled methylester group of pectin, 13 C-enriched methanol is produced and then converted to 13 C-enriched CO 2 , which can be detected as the final product of this process by gas chromatography-isotope-ratio-mass spectrometry (Supplementary Figure 2)

For each participant, an individual mean baseline value was calculated as the arithmetic mean of the two measured baseline concentrations, and this mean value was subtracted from each concentration value measured on Days 12 and 67

Iron-deficient people will suffer or die from organ damage well before their cells run out of the iron needed for intracellular processes like electron transport

10.1016/j.biopsych.2012.09.010 Biol