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Reactive oxygen species can be beneficial, as against pathogens, and are also used in cell signalling

In fact, glutathione depletion is linked with a number of disease states and groups: Aging Athletic overtraining Major injuries and trauma Patients with wasting diseases such as HIV and AIDS Lung cancer Gut-based diseases such as Crohns and ulcerative colitis Chronic fatigue syndrome Alcoholism and fatty liver disease Diabetes and low glucose tolerance Cancer One of the most important things you can do to improve glutathione status is to remove or mitigate stressors that deplete glutathione

Most milder Vitamin C serums that are formulated to mitigate irritation simply dont perform

F.QiuM.et al

Exp Biol Med (maywood) 239(1):612

Even a modest reduction in Vitamin B 12 status will cause elevation of plasma homocysteine (Scott, 12 deficiency