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However, resistance to enzalutamide has now also been identified as a result of an Phe876Leu point mutation in the LBD (213) and the expression of NH 2 -terminal domain splice variants (163) in CRPC, emphasizing the need for continued research and development of strategies to switch off androgen receptor signaling

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During l-carnitine catabolism by human gut commensals and fecal polymicrobial anaerobic cultures, BB accumulates as an intermediate before it is anaerobically converted to TMA

Patient serum samples and outcomes data Pretreatment (pre-surgery and pre-chemotherapy) blood was collected from patients with newly diagnosed epithelial ovarian cancer under University of Pittsburgh approved IRB protocols 20050019, 19070449 and 19060197