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BJU international 110 , 13461351, (2012)

HSP90 directly interacts with GPX4, inhibiting GPX4 activity and resulting in ferroptosis [112]

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The authors research whether TB-500 may tone down this signaling and suggest that the peptide may increase the level of miR-146a, a small regulatory RNA molecule whose role may be to act as an internal brake on inflammatory signaling pathways