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While BPA binding to extranuclear ER can trigger MAPK pathway activation 78 , the observed activation of the intracellular kinase pathways observed here more probably occurred via BPA binding to GPER, the G-protein coupled ER, as membrane bound ERs have not been identified in zebrafish 74

This mechanistically supports the use of such vitamin antioxidant combinations for DR [44, 50]

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This assumption is based on in vitro experiments after transient transfection of androgen receptor cDNA's containing (CAG)nCAA - repeats of different lengths (70, 71)

Mol Syst Des Eng 9:847855 DeRosa MC, Lin A, Mallikaratchy P et al (2023) In vitro selection of aptamers and their applications