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Sung H, Ferlay J, Siegel RL, Laversanne M, Soerjomataram I, Jemal A

A deficiency of any of the B vitamins could potentially keep the rest of the group from performing their proper functions

Conformational change Many Env spikes are metastable on the virion surface they are in a pre-fusion conformation, and interaction with host cell receptors triggers extensive structural changes that allow for the viral entry process