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Targeted xCT-mediated Ferroptosis and Protumoral Polarization of Macrophages Is Effective against HCC and Enhances the Efficacy of the Anti-PD-1/L1 Response

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The groundbreaking innovation of smart responsive hydrogels lies in their ability to dynamically sense pathological cuesincluding pH fluctuations, ROS levels, MMP activity, and mechanical stresstransforming them from singular therapeutic agents into programmable cellular carrier platforms

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