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( a ) Coloc and moloc analysis overlap for eGFR GWAS, and kidney eQTL, and pQTL: Venn diagram illustrating the intersection between proteins and genes identified as significant in coloc analysis and further refined by moloc analysis

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Inhibition of MT1-MMP restores IR expression, improving insulin sensitivity and glucose tolerance in both aged mice and diabetic mouse models

However, in contrast to the tumour-suppressive effects described above, there is evidence that CDO1 can have a tumorigenic effect associated with aggressive glioblastoma, since its overexpression was detected in these tumours