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ERRs are members of the nuclear receptor superfamily of ligand-activated transcription factors, though unlike most nuclear receptors, ERRs are constitutively active and were long thought to be "orphan" receptors lacking endogenous ligands

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K., Potempa, M

Vitamin E for the treatment of children with hepatitis B e antigen-positive chronic hepatitis: a systematic review and meta-analysis

However, recent studies have shown them to be important in modulating the innate immune response [105, 106, 107]

In STZ-diabetic rats, treadmill exercise reduced retinal apoptosis (TUNEL+cells, Bax/Bcl-2 ratio, caspase-3 activation) and restored p-Akt levels in the retina, indicating activation of survival signaling in the diabetic neurovascular unit (242)