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Cancer Cell 31 , 820832.e823 (2017)

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Chronic oxidative stress promotes GADD34-mediated phosphorylation of the TAR DNA-binding protein TDP-43, a modification linked to neurodegeneration

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The molecular mechanisms and regulatory networks of oxeiptosis have not been fully elucidated, but studies have shown its importance in a variety of biological functions, such as the loss of PGAM5 and AIFM1, which are associated with neurological dysfunction, and KEAP1 mutations, which are associated with lung and prostate cancer ( In CNS diseases, the role of oxeiptosis is gradually being revealed, especially in Alzheimers disease, where the expression of proteins associated with this pathway is upregulated, hinting at its role in oxidative stress and mitochondrial damage