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In this case, you start from a diverse population of molecules, then select for particular proteins, and reproduce that molecule

Most of these can be classified as covalent inhibitors, with an advantage that they do not easily promote bacterial drug resistance [172,173,174]

In contrast, the canonical isoform showed variable, typically low acetylation

10.1038/s41418-020-00685-9 12 BartzokisG.TishlerT

For LC-MS analysis, samples were thawed on ice-water bath, then 40 L of whole blood was injected into 450 L cold extraction solvent comprising of mixture of Acetonitrile:Methanol:Milli-Q water in ratio 40:40:20 according to protocol described in Presterud et al 35

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