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ROS-induced mitochondrial dysfunction and DNA damage, along with the inhibition of key redox transcription factors such as Nuclear Factor Erythroid 2-Related Factor 2 (NRF2) may contribute to the persistence of symptoms in both ME/CFS and Long COVID (Jarrott et al., 2022)

for example, these cells can distinguish between gram-positive and gram-negative bacteria (84)

extreme tiredness (fatigue) shortness of breath chest pain or tightness problems with memory and concentration (brain fog) difficulty sleeping (insomnia) heart palpitations dizziness pins and needles joint pain depression and anxiety tinnitus, earaches feeling sick, diarrhoea, stomach aches, loss of appetite a high temperature, cough, headaches, sore throat, changes to sense of smell or taste rashes Ah

10.1042/BJ20090224 Biochem

10.1002/ejlt.201600077 Eur J Lipid Sci Technol

To monitor cell viability, the cells were trypsinized, and apoptosis/necrosis induced by pneumococcal infection was evaluated using flow cytometry with an Annexin V/propidium iodide labeling kit (Invitrogen), showing 5% across all time points