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[DOI] [PMC free article] [PubMed] [Google Scholar] 90.Fimognari C., Hrelia P

Diabetes-associated mutations in insulin identify invariant receptor contacts

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LHON is caused by mutations in the mitochondrial DNA, particularly in genes encoding the subunits of complex I of the mitochondrial electron transport chain such as MT-ND1 , MT-ND4 , and MT-ND6

The ATP-dependent proteolytic complex, called the 26S proteasome, then recognizes the polyubiquitin protein and degrades it into small peptide fragments 18