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Hydroperoxides can activate catalytic reactions in the presence of transition metals such as iron, which eventually leads to ferroptosis

doi: 10.1371/journal.ppat.1007724 173 LachmandasEVan Den HeuvelCNAMDamenMSMACleophasMCPNeteaMGVan CrevelR

studied and revealed this novel cell death mechanism dependent on copper, known as cuproptosis [94], which also explains the antitumor mechanism of Cu-MOFs