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Since we previously found that ser/gly rewired tumors produce and secrete high levels of pathway metabolites into the circulation, we hypothesized that metabolomic analysis of blood plasma samples from patients with NSCLC could give valuable insight into ser/gly metabolic rewiring in tumor cells in response to RT [24]

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Figure 1 Gross pathological changes expected in this disease model included increased lung mass, increased cellularity of the bronchoalveolar lavage fluid (BALF), epithelial thickening, and pockets of immune cell infiltrations in the lung parenchyma