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Premature ageing in mice expressing defective mitochondrial DNA polymerase

Exp Cell Res 334:136145 Xu Q, Langley M, Kanthasamy AG, Reddy MB (2017) Epigallocatechin gallate has a neurorescue effect in a mouse model of Parkinson disease

2.9.1 Phase 1 A total of 48 female Mus musculus C57BL/6 (FMO3 +/+) strain WT mice, who were 8 weeks old, were divided into eight groups: six groups were based on the compound to be tested and the other two groups were, respectively, the positive control (FMC treatment) and the negative control (only phosphate-buffered saline treatment)

however, a progressive decline was observed after 10 weeks

Indirect calorimetry was performed for 45 min in the 5th h