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Finally, enrichment analysis of the significant signal transduction pathways based on the differential metabolites was carried out using KEGG

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Afatinib versus methotrexate as second-line treatment in Asian patients with recurrent or metastatic squamous cell carcinoma of the head and neck progressing on or after platinum-based therapy (LUX-Head & Neck 3): an open-label, randomised phase III trial

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In addition, Pycnogenol was shown to lower glycated hemoglobin by 10% in the Pycnogenol group, a significant effect compared to placebo