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Through these mechanisms, HSP70 and HSP90 reduce the formation of neurofibrillary tangles, thereby mitigating one of the core pathological processes underlying tau-mediated neurodegeneration

Curr Neurol Neurosci Rep 13:394

The pathophysiologically relevant mutations mainly occur in the region of the APP gene that encodes for the recognition sequences of the secretase proteases

On the other hand, dysbiosis, which is an imbalance in the populations of microorganisms in the gut, may hinder Se absorption, resulting in suboptimal levels that may impact thyroid function [55]

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