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P.FujiedaS

MitoROS production involves several key steps: (1) Complexes I, II, and III of the respiratory chain: Complex I (NADH dehydrogenase) and complex II (succinate dehydrogenase) on the IMM convert H + to coenzyme Q, releasing electrons in the process

In addition, the GPx defends against oxidants that cause neuronal and protein damage, which reduce H 2 O 2 and lipid peroxide to water and alcohol, respectively

Dopamine agonists, including rotigotine, ropinirole, and pramipexole directly stimulate dopamine receptors and can delay the need for levodopa in early-stage PD 53,54