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doi: 10.1105/tpc.108.058594 257 SpicherL.AlmeidaJ.GutbrodK.PipitoneR.DrmannP.GlauserG.et al

Although atypical, other groups have reported ligand-independent means of nuclear hormone receptor regulation 62 , and we further investigated whether this might be the case for NHR-49 during fasting conditions

However, this debris (particularly myelin) is rich in iron

In terms of payload design, there has been a transition from classical microtubule inhibitors (e.g., MMAE, DM1) to DNA-damaging agents (e.g., calicheamicin, PBD) and topoisomerase I inhibitors (e.g., SN-38, deruxtecan) [99, 104, 110, 132]