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NAD+ levels naturally decline with age, contributing to fatigue, brain fog, and accelerated aging

Alpha-ketoglutarate (-KG), which is derived from glutamine catabolism, is an important anaplerotic substrate of the TCA cycle

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10.1021/acs.chemrev.7b00205 Chem

In addition, the classical ferroptosis inducer erastin was also reported to damage cardiomyocytes by initiating ferroptosis, while ENPP2, a lipid kinase generating the lipid mediator lysophosphatidic acid, could protect cardiomyocytes from the erastin-induced ferroptosis by decreasing ROS generation [107]