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- Antioxidants (e.g., vitamin C) can reduce the effectiveness of chemotherapeutics (e.g., cisplatin) by combating oxidative stress, a mechanism used by pharmaceutical substances to destroy tumor cells

Autoantibodies, polymorphisms in the serotonin pathway, and human leukocyte antigen class II alleles in chronic fatigue syndrome: are they associated with age at onset and specific symptoms

Venter et al

Because Prozac is also processed in the liver, a liver that isnt working well wont clear the medication the way it should

In summary, PTDSS1 deficiency induces GSH depletion and oxidative stress, activating the PINK1/Parkin/MFN2 mitophagy pathway and promoting ferroptosis and apoptosis in tumor cells

Lack of SIRT1 can lead to a significant increase in ROS levels and inflammatory response, increasing NAD+ can activate SIRT1, such as resveratrol and some probiotics in breast milk