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Electrolyte imbalances: Adding minerals to an already dysregulated electrolyte environment requires careful assessment

High-iron diets in rats elevate A deposition and tau phosphorylation, whereas iron chelators can mitigate these effects (295)

The improved functioning of the BBB, enhanced clearance of metabolites and protein fragments implicated in AD from the brain - an astrocyte-dependent mechanism primarily occurring during sleep [14] - and enhanced insulin signaling, suggested to play a role in AD [33], present additional mechanisms by which melatonin may impact AD pathology

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The development and progression of T-cell malignancies rely on various pathways involved in metabolic regulation (120)

Cell 73 , 166182.e7 (2019)