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[3] [34] In mammals, five subtypes of dopamine receptors have been identified, labeled from D 1 to D 5

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Such extranuclear mtDNA acts as a potent DAMP, capable of activating innate immune sensors including cGAS, TLR9, and the NOD, LRR and pyrin domain-containing protein 3 (NLRP3) inflammasome, thus triggering neuroinflammatory cascades [32,33,34]

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