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Preclinical studies in rodents have shown an association between GLP-1 receptor activation and thyroid C-cell changes, although a direct causal link in humans has not been established, and UK/EU SmPCs for authorised GLP-1 RAs do not list MTC or MEN2 as a formal contraindication

Suzuki T, Morita M, Kobayashi Y, Kamimura A

Lysyl oxidase Copper-dependent enzyme that catalyzes the oxidative deamination of lysine residues in collagen and elastin, producing aldehydes that participate in cross-linking reactions essential for mature extracellular matrix mechanical properties

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Interactions with medications These supplements need careful handling when mixed with certain medicines