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Upon exposure to oxidative or electrophilic stress, critical cysteine residues on Keap1 are modified, resulting in the stabilization and nuclear accumulation of Nrf2

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Sadiq et al., 2000)

To move beyond basic cell culture, the study incorporated ex vivo skin models

Mitochondria, as the epicenter of energy metabolism, intricately regulate amino acid, carbohydrate, and lipid metabolism, influencing ferroptosis

This exchange is stimulated by the presence of high extracellular concentrations of OA 7 and is driven by the electrochemical gradient of GSH across the plasma membrane