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However, while iNOS is up-regulated in patients with CHF producing high circulating levels, eNOS is down-regulated thus reducing endothelium-dependent vasodilation

These vessels are part of the immune system and are responsible for draining fluids and transporting immune cells throughout the body

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Following this, saline, free MCMs, SP, and SP@M were then intravenously injected into CIA mice every three days

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