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In 1928, chemist Edwin Cohn prepared an extract that was 50 to 100 times stronger than obtained from raw liver

Renal physiology 301, F134-150, doi:10.1152/ajprenal.00033.2011 (2011)

37 Dalmatian Dalmatians are reported to have acute hepatic necrosis, chronic hepatitis, and cirrhosis associated with increased hepatic copper concentrations.35, 102 Cholestasis is not a prominent biochemical or histologic feature until later in the disease, suggesting that hepatic copper accumulation is more likely to be caused by a familial metabolic disorder rather than secondary to altered hepatic biliary copper excretion

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Vasorelaxant mode of action of dichloromethane-soluble extract from Agastache mexicana and its main bioactive compounds